Comparison of demographics and outcome among three subgroups
| Mild stroke n=865 | Moderate stroke n=1784 | Severe stroke n=807 | P value | |
| Number of lower dosage (%) | 106 (12.25) | 212 (11.88) | 105 (13.01) | 0.719 |
| Age (years), n | <0.001 | |||
| <45 | 39 | 95 | 17 | |
| 45–64 | 464 | 803 | 269 | |
| ≥65 | 357 | 872 | 515 | |
| Sex: male, n (%) | 583 (67.40) | 1193 (66.87) | 463 (57.37) | <0.0001 |
| Median onset to needle, hours | 2.933 | 2.833 | 2.667 | <0.0001 |
| History and risk factors, n (%) | ||||
| Hypertension | 526 (60.81) | 1051 (58.91) | 503 (62.33) | 0.235 |
| Diabetes | 185 (21.39) | 378 (21.19) | 156 (19.33) | 0.496 |
| Stroke | 82 (9.48) | 220 (12.33) | 132 (16.36) | 0.0001 |
| TIA | 17 (1.97) | 71 (3.98) | 37 (4.58) | 0.008 |
| Atrial fibrillation | 59 (6.82) | 266 (14.91) | 273 (33.83) | <0.0001 |
| Outcome, n (%) | ||||
| sICH | 17 (1.97) | 59 (3.31) | 71 (8.80） | <0.0001 |
| Clinical improvement | 582 (67.3) | 1080 (60.5) | 475 (58.9) | 0.0001 |
Groups: mild: NIHSS 0–4; moderate: NIHSS 5–14; severe: NIHSS ≥15.
NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; TIA, transient ischaemic attack.