Table 2

Headache attributed to cerebrovascular diseases with clinical and diagnostic features

TypesHeadache featuresDiagnostic features
SAHThunderclap, acute, severe, long-lastingNon-contrast-enhanced CT: sensitivity 99% in the first 6 hours, CSF: erythrocytes or xanthochromia
PACNSChronic, moderate, diffuse, long-lastingCSF: lymphocyte and protein increases, MRI: ischaemic lesions in subcortical and deep white matter and grey matter
CADThunderclap, acute, unilateralCT or MRA: long, irregular stenosis, an occlusion or a dissecting aneurysm
CVTAcute or subacute, diffuse, long-lastingMRI: detect brain parenchymal lesions; CT/CTV: high density consistent with the position of venous sinus
MELASMigrainous headaches, short-lasting, mild or moderateMRI: lace sign or ribbon sign
CADASILMigraine with (atypical) auraMRI: white matter hyperintensities in the anterior temporal pole, lacunes; genetic testing: NOTCH3 mutation
RCVSThunderclap, acute, severe, relapsingAngiography: segmental narrowing of branches of cerebral arteries
  • CAD, cervical artery dissection; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy; CSF, cerebrospinal fluid; CTV, CT venography; CVT, cerebral venous thrombosis; MELAS, mitochondrial encephalomyopathy, lactic acidosis and stroke-like episode syndrome; MRA, magnetic resonance angiography; PACNS, primary angiitis of the central nervous system; RCVS, reversible cerebral vasoconstriction syndrome; SAH, subarachnoid haemorrhage.