Table 4

Multivariate regression for the association between CSVD or ICAS burdens and the 3-month prognosis in the entire cohort

		Model 1*		Model 2†
		Adjusted HR/cOR (95% CI)	P value	Adjusted HR/cOR (95% CI)	P value
New stroke
CSVD burden score	0	1		1
	1–2	1.69 (0.90 to 3.19)	0.10	1.45 (0.76 to 2.77)	0.27
	3–4	1.21 (0.58 to 2.52)	0.60	0.91 (0.42 to 1.97)	0.82
Modified CSVD burden score	0	1		1
	1–2	1.25 (0.72 to 2.16)	0.42	1.10 (0.62 to 1.93)	0.75
	3–6	0.88 (0.40 to 1.91)	0.74	0.67 (0.29 to 1.53)	0.34
ICAS segment	0	1		1
	1	1.88 (1.10 to 3.23)	0.02	1.75 (1.01 to 3.05)	0.047
	>1	2.36 (1.38 to 4.04)	0.002	2.03 (1.15 to 3.56)	0.01
Any bleeding
CSVD burden score	0	1		1
	1–2	3.53 (0.43 to 29.16)	0.24	3.65 (0.43 to 31.21)	0.23
	3–4	8.21 (1.00 to 67.48)	0.05	10.70 (1.16 to 99.04)	0.04
Modified CSVD burden score	0	1		1
	1–2	5.70 (0.66 to 49.47)	0.11	14.87 (0.95 to 233.69)	0.05
	3–6	12.44 (1.36 to 115.46)	0.03	48.65 (2.10 to 1124.88)	0.02
ICAS segment	0	1		1
	1	0.79 (0.27 to 2.35)	0.67	0.88 (0.28 to 2.76)	0.83
	>1	0.69 (0.19 to 2.58)	0.59	0.82 (0.20 to 3.39)	0.78
mRS score
CSVD burden score	0	1		1
	1–2	1.45 (1.04 to 2.03)	0.03	1.35 (0.94 to 1.94)	0.10
	3–4	2.01 (1.40 to 2.89)	<0.001	1.46 (0.98 to 2.17)	0.06
Modified CSVD burden score	0	1		1
	1–2	1.53 (1.13 to 2.08)	0.007	1.42 (1.02 to 1.98)	0.04
	3–6	2.15 (1.45 to 3.21)	<0.001	1.55 (1.00 to 2.40)	0.05
ICAS segment	0	1		1
	1	1.73 (1.29 to 2.32)	<0.001	1.80 (1.31 to 2.45)	<0.001
	>1	2.15 (1.57 to 2.93)	<0.001	1.98 (1.42 to 2.75)	<0.001

*Model 1: CSVD burden and ICAS segment were included in the same model, and the model was simultaneously adjusted for age, gender, premorbid mRS score and antiplatelet therapy.
†Model 2: CSVD burden and ICAS segment were included in the same model, and the model was simultaneously adjusted for age, gender, premorbid mRS score, antiplatelet therapy, body mass index, history of ischaemic stroke, TIA, myocardial infarction, congestive heart failure, known atrial fibrillation or flutter, hypertension, diabetes, hypercholesterolaemia, smoking status, time to randomisation, qualifying event and NIHSS score on admission.
cOR, common OR; CSVD, cerebral small vessel disease; ICAS, intracranial arterial stenosis; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.