Table 3

The association between CSVD/ICAS status and the 3-month new stroke and bleeding events

No.Event, n (%)Adjusted HR* (95% CI)P value
New stroke
No CSVD without ICAS1297 (5.4)1
CSVD without ICAS45624 (5.3)0.89 (0.37 to 2.16)0.801
No CSVD with 1 ICAS492 (4.1)0.64 (0.13 to 3.19)0.584
CSVD with 1 ICAS20124 (12.0)1.84 (0.74 to 4.58)0.193
No CSVD with ＞1 ICAS374 (10.8)1.64 (0.45 to 5.97)0.451
CSVD with ＞1 ICAS17325 (14.5)2.03 (0.80 to 5.14)0.138
Bleeding events
No CSVD without ICAS1291 (0.8)1
CSVD without ICAS45613 (2.9)2.88 (0.35 to 23.6)0.33
No CSVD with 1 ICAS490N.A.N.A.
CSVD with 1 ICAS2015 (2.5)2.87 (0.30 to 27.8)0.36
No CSVD with ＞1 ICAS370N.A.N.A.
CSVD with ＞1 ICAS1734 (2.3)2.10 (0.18 to 24.2)0.55

  • *This model was adjusted for age, gender, premorbid mRS score, antiplatelet therapy, body mass index, history of ischaemic stroke, TIA, myocardial infarction, congestive heart failure, known atrial fibrillation or flutter, hypertension, diabetes, hypercholesterolaemia, smoking status, time to randomisation, qualifying event and NIHSS score on admission.

  • CSVD, cerebral small vessel disease; ICAS, intracranial arterial stenosis; mRS, modified Rankin Scale; N.A., not available; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.