Comparison in demographic profiles between the imaging substudy population and the excluded population
| Characteristics | Population in imaging substudy (n=1045) | The excluded population (n=4125) | P value |
| Age, years, median (IQR) | 63.2 (55.6–72.0) | 61.9 (54.4–71.1) | 0.002 |
| Female, n (%) | 363 (34.7) | 1387 (33.6) | 0.50 |
| BMI, median (IQR) | 24.2 (22.4–26.1) | 24.6 (22.9–26.6) | <0.001 |
| Medical history, n (%) | |||
| Ischaemic stroke | 179 (17.1) | 854 (20.7) | 0.01 |
| TIA | 31 (3.0) | 143 (3.5) | 0.42 |
| Myocardial infarction | 19 (1.8) | 77 (1.9) | 0.92 |
| Congestive heart failure | 19 (1.8) | 61 (1.5) | 0.43 |
| Known atrial fibrillation or flutter | 21 (2.0) | 75 (1.8) | 0.68 |
| Valvular heart disease | 4 (0.4) | 10 (0.2) | 0.66 |
| Diabetes | 222 (21.2) | 871 (21.1) | 0.93 |
| Hypertension | 682 (65.3) | 2717 (65.9) | 0.71 |
| Hyperlipidaemia | 133 (12.7) | 440 (10.7) | 0.06 |
| Currently or previously smoking, n (%) | 433 (41.4) | 1788 (43.3) | 0.27 |
| Mean time to randomisation, hour, median (IQR) | 12.0 (7.1–19.5) | 12.0 (6.1–19.5) | 0.02 |
| Qualifying event, n (%) | |||
| Minor stroke | 793 (75.9) | 2932 (71.1) | 0.002 |
| TIA | 252 (24.1) | 1193 (28.9) | |
| NIHSS score on admission, median (IQR) | 2 (0–2) | 1 (0–2) | 0.009 |
BMI, body mass index; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.