Table 2

Major studies of flowdiverter devices

Flow diverterAuthor, yearPatients, aneurysms (n)Type of aneurysms treatedOcclusion rateMorbidity (%), mortality (%)
PEDLylyk et al, 200914 53, 63Wide-necked large and giant aneurysms for which previous treatment attempts failed93% at 6 months5; 0
 Szikora et al, 201015 18, 19Large, giant, fusiform or wide-necked aneurysms94.4% at 6 months5.5, 5.5
 Nelson et al, 2011 (PITA)13 31, 31Unruptured wide-necked aneurysms or failed previous therapy93.3% at 6 months6.5, 0
 Becske et al, 2013 (PUFS)16 108, 108Unruptured large/giant wide-necked aneurysms of proximal ICA73.6% at 6 months, 86.8% at 1 year, 93.4% at 3 years and 95.2% at 5 years2.8, 2.8
 Atasoy et al, 2019 (PEDSU)17 41, 44Mostly large/giant, wide-neck, saccular aneurysms78.8% at 6 months and 90.3% at 18 months6.8, 2.3
PED Shield Trivelato et al, 201918 151, 182Mostly large and giant aneurysms, mostly saccular79.7% at 6 months, 85.3% at 1 year6.0, 0.7
SurpassDe Vries et al, 201319 37, 49Unruptured, complex, mostly saccular ICA aneurysms94% at 6 months3, 0
 Wakhloo et al, 201520 165, 190Mostly unruptured, anterior circulation, wide-necked ICA aneurysms75% at 6 months6.0, 2.7
 Meyers et al, 2019 (SCENT)21 180, 180Uncoilable or previously treated but failed ICA aneursyms62.8% at 1 year8.3, 2.2
SilkLubicz et al, 201023 29, 34Fusiform or wide-necked, unruptured aneurysms69% at 6 months15, 4
 Berge et al, 201224 65, 77Unruptured or recanalised, saccular aneurysms68% at 6 months, 84.3% at 1 year7.8, 3
 Shankar et al, 2016103 92, 103Mostly unruptured saccular ICA aneurysms83.1% (median 1 year)8.7, 2.2
 Pumar et al, 2017104 157, 180Unruptured, saccular ICA aneurysms78.1% at 1 year9.6, 3.2
 Foa Torres et al, 201825 246, 293Unruptured, saccular ICA aneurysms93.9% at 1 year4.2, 2.1
Silk+Lubicz et al, 201526 58, 70Saccular and fusiform aneurysms73% (mean follow-up of 22 months)5.5, 0
FREDMöhlenbruch et al, 201528 29, 34Mixture of wide-neck saccular, fusiform/dissecting, large/giant aneurysms73% at 6 months3.4, 0
 Pierot et al, 2019 (SAFE)27 103, 103Unruptured saccular aneurysms73.3% at 1 year2.9; 1.9
 Piano et al, 201929 162, 165Mostly unruptured, saccular or fusiform/dissecting aneurysms96% at 12–24 months7.3 (6.2 related to FRED), 4.3 (2.4 related to FRED)
DerivoAkgul et al, 201631 24, 34Wide-necked, mostly medium-sized and fusiform aneurysms71.4% at 3 months, 77.8% at 9 months8.4, 4.3
 Daglioglu et al, 201932 146, 182Mean aneurysm size was 8.3 mm78.7% at 7.02 months3.4, 2.7
 Trivelato et al, 201930 (BRAIDED)146, 183Mostly saccular and unruptured aneurysms80.7% at 6 months, 89.2% at 1 year4.1, 1.4
P64Fischer et al, 201533 121, 130Mostly unruptured, saccular sidewall aneurysms79.6% at 9 months1.7, 0.8
 Briganti et al, 201734 40, 50Mostly unruptured, small, saccular ICA aneurysms88% at 6–24 months2.5, 0
 Morais et al, 201765 39, 48Mostly unruptured, saccular aneurysms66.6% at 6 months, 85.7% at 1 year0, 0
 Sirakov et al, 201935 72, 72Mostly saccular aneurysms91.4% at 1 year, 98.5% at 2 years, 100% at 3 years1.4, 0
TubridgeZhou et al, 201437 28, 28Large or giant ICA aneurysms72% at mean 9.9 months0, 0
 Liu et al, 2018 (PARAT)36 82, 82Mostly unruptured large/giant aneurysms of ICA75.3% at 6 months2.4, 1.6
FloWiseKim et al, 201938 10, 14Paraclinoid or ophthalmic ICA aneurysms66.7% at 6 months, 83.3% at 1 year0, 0

  • FRED, Flow-Redirection Endoluminal Device; ICA, internal carotid artery; PARAT, Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter; PEDSU, Pipeline Embolization Device with Shield Technology in Unruptured Aneurysms; PITA, Pipeline Embolization Device for the Intracranial Treatment of Aneurysm; PUFS, Pipeline Embolization Device for Uncoilable or Failed Aneurysms; SAFE, Safety and Efficacy Analysis of FRED Embolic Device in Aneurysm Treatment; SCENT, Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms.