Flow diverter | Author, year | Patients, aneurysms (n) | Type of aneurysms treated | Occlusion rate | Morbidity (%), mortality (%) |
PED | Lylyk et al, 200914 | 53, 63 | Wide-necked large and giant aneurysms for which previous treatment attempts failed | 93% at 6 months | 5; 0 |
Szikora et al, 201015 | 18, 19 | Large, giant, fusiform or wide-necked aneurysms | 94.4% at 6 months | 5.5, 5.5 | |
Nelson et al, 2011 (PITA)13 | 31, 31 | Unruptured wide-necked aneurysms or failed previous therapy | 93.3% at 6 months | 6.5, 0 | |
Becske et al, 2013 (PUFS)16 | 108, 108 | Unruptured large/giant wide-necked aneurysms of proximal ICA | 73.6% at 6 months, 86.8% at 1 year, 93.4% at 3 years and 95.2% at 5 years | 2.8, 2.8 | |
Atasoy et al, 2019 (PEDSU)17 | 41, 44 | Mostly large/giant, wide-neck, saccular aneurysms | 78.8% at 6 months and 90.3% at 18 months | 6.8, 2.3 | |
PED Shield | Trivelato et al, 201918 | 151, 182 | Mostly large and giant aneurysms, mostly saccular | 79.7% at 6 months, 85.3% at 1 year | 6.0, 0.7 |
Surpass | De Vries et al, 201319 | 37, 49 | Unruptured, complex, mostly saccular ICA aneurysms | 94% at 6 months | 3, 0 |
Wakhloo et al, 201520 | 165, 190 | Mostly unruptured, anterior circulation, wide-necked ICA aneurysms | 75% at 6 months | 6.0, 2.7 | |
Meyers et al, 2019 (SCENT)21 | 180, 180 | Uncoilable or previously treated but failed ICA aneursyms | 62.8% at 1 year | 8.3, 2.2 | |
Silk | Lubicz et al, 201023 | 29, 34 | Fusiform or wide-necked, unruptured aneurysms | 69% at 6 months | 15, 4 |
Berge et al, 201224 | 65, 77 | Unruptured or recanalised, saccular aneurysms | 68% at 6 months, 84.3% at 1 year | 7.8, 3 | |
Shankar et al, 2016103 | 92, 103 | Mostly unruptured saccular ICA aneurysms | 83.1% (median 1 year) | 8.7, 2.2 | |
Pumar et al, 2017104 | 157, 180 | Unruptured, saccular ICA aneurysms | 78.1% at 1 year | 9.6, 3.2 | |
Foa Torres et al, 201825 | 246, 293 | Unruptured, saccular ICA aneurysms | 93.9% at 1 year | 4.2, 2.1 | |
Silk+ | Lubicz et al, 201526 | 58, 70 | Saccular and fusiform aneurysms | 73% (mean follow-up of 22 months) | 5.5, 0 |
FRED | Möhlenbruch et al, 201528 | 29, 34 | Mixture of wide-neck saccular, fusiform/dissecting, large/giant aneurysms | 73% at 6 months | 3.4, 0 |
Pierot et al, 2019 (SAFE)27 | 103, 103 | Unruptured saccular aneurysms | 73.3% at 1 year | 2.9; 1.9 | |
Piano et al, 201929 | 162, 165 | Mostly unruptured, saccular or fusiform/dissecting aneurysms | 96% at 12–24 months | 7.3 (6.2 related to FRED), 4.3 (2.4 related to FRED) | |
Derivo | Akgul et al, 201631 | 24, 34 | Wide-necked, mostly medium-sized and fusiform aneurysms | 71.4% at 3 months, 77.8% at 9 months | 8.4, 4.3 |
Daglioglu et al, 201932 | 146, 182 | Mean aneurysm size was 8.3 mm | 78.7% at 7.02 months | 3.4, 2.7 | |
Trivelato et al, 201930 (BRAIDED) | 146, 183 | Mostly saccular and unruptured aneurysms | 80.7% at 6 months, 89.2% at 1 year | 4.1, 1.4 | |
P64 | Fischer et al, 201533 | 121, 130 | Mostly unruptured, saccular sidewall aneurysms | 79.6% at 9 months | 1.7, 0.8 |
Briganti et al, 201734 | 40, 50 | Mostly unruptured, small, saccular ICA aneurysms | 88% at 6–24 months | 2.5, 0 | |
Morais et al, 201765 | 39, 48 | Mostly unruptured, saccular aneurysms | 66.6% at 6 months, 85.7% at 1 year | 0, 0 | |
Sirakov et al, 201935 | 72, 72 | Mostly saccular aneurysms | 91.4% at 1 year, 98.5% at 2 years, 100% at 3 years | 1.4, 0 | |
Tubridge | Zhou et al, 201437 | 28, 28 | Large or giant ICA aneurysms | 72% at mean 9.9 months | 0, 0 |
Liu et al, 2018 (PARAT)36 | 82, 82 | Mostly unruptured large/giant aneurysms of ICA | 75.3% at 6 months | 2.4, 1.6 | |
FloWise | Kim et al, 201938 | 10, 14 | Paraclinoid or ophthalmic ICA aneurysms | 66.7% at 6 months, 83.3% at 1 year | 0, 0 |
FRED, Flow-Redirection Endoluminal Device; ICA, internal carotid artery; PARAT, Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter; PEDSU, Pipeline Embolization Device with Shield Technology in Unruptured Aneurysms; PITA, Pipeline Embolization Device for the Intracranial Treatment of Aneurysm; PUFS, Pipeline Embolization Device for Uncoilable or Failed Aneurysms; SAFE, Safety and Efficacy Analysis of FRED Embolic Device in Aneurysm Treatment; SCENT, Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms.