Table 2

Univariable analysis of sex-specific associations with NAWM K 2 coefficient

VariableWomenMen
EstimateP valuesEstimateP values
Age11.30.1736.0 0.04
BMI−41.80.06−64.00.20
Anticoagulant use523.80.202.90.99
Atrial fibrillation583.6 0.04 −935.30.12
Diabetes−118.60.75603.20.29
Hyperlipidaemia82.60.77613.20.20
Hypertension−123.40.67−362.20.51
Prior stroke/TIA336.70.30650.60.24
Cardioembolic stroke194.60.4866.70.89
Admission NIHSS40.40.0731.40.40
Systolic blood pressure0.90.868.00.36
MMP-2 level0.40.691.40.45
IV alteplase treatment195.50.48−732.60.15
HT413.40.17357.10.52
WMHv31.8 0.04 131.1 0.005
NAWM ADC4.4 0.02 2.20.66
NAWM mask volume−17.80.11−24.00.13
  • Bold values indicate P value < 0.05.

  • ADC, apparent diffusion coefficient; BMI, body mass index; HT, haemorrhagic transformation; IV, intravenous; MMP, matrix metalloproteinase; NAWM, normal-appearing white matter; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischemic attack; WMHv, white matter hyperintensity volume.