Table 2

Domain-specific cognitive z-scores in no atrophy, CA and CA+MTA groups in different CeVD groups

Groups
Cognitive scoresNone-mild CeVDModerate-severe CeVDP
(for trend)
No atrophy (n=362)CA (n=133)CA+MTA (n=25)No atrophy (n=109)CA (n=132)CA+MTA (n=58)
Executive function0.27
(0.18, 0.36)		0.23
(0.10, 0.37)		−0.21
(−0.53,0.11)		0.19
(0.03, 0.34)*		0.07
(−0.10, 0.23)†		−0.33
(−0.64,–0.02)*†		0.002
Attention0.28
(0.19, 0.36)		0.22
(0.08, 0.36)		−0.04
(−0.37, 0.28)		0.16
(0.01, 0.32)		−0.20
(−0.37,–0.03)		−0.35
(−0.66,–0.04)		0.001
Language0.28
(0.19, 0.36)		0.22
(0.08, 0.36)		−0.04
(−0.37, 0.28)		0.16
(0.01, 0.32)		−0.20
(−0.37,–0.04)		−0.35
(−0.66,–0.04)		<0.001
Verbal memory0.35
(0.26, 0.44)		0.23
(0.09, 0.38)		−0.19
(−0.52, 0.14)		0.08
(−0.08, 0.24)		0.01
(−0.16, 0.18)		−0.25
(−0.56,0.07)		<0.001
Visual memory0.33
(0.25, 0.41)		0.27
(0.14, 0.40)		−0.23
(−0.53, 0.07)		0.19
(0.04, 0.33)*		−0.12
(−0.27, 0.03)		−0.39
(−0.67,–0.11)*		<0.001
Visuoconstruction0.30
(0.21, 0.38)		0.24
(0.10, 0.38)		−0.30
(−0.63, 0.02)		0.09
(−0.06, 0.25)		0.04
(−0.12, 0.21)		−0.09
(−0.39, 0.22)		0.002
Visuomotor speed0.31
(0.23, 0.39)		0.18
(0.05, 0.30)		−0.29
(−0.57, 0.003)		0.11
(−0.03, 0.24)*		0.09
(−0.05, 0.24)†		−0.22
(−0.49, 0.06)†		<0.001

  • Values are adjusted means (95% CI). CeVD, Cerebrovascular Disease. The model controlled for age, education, gender and cognitive impairment status.

  • *Significant difference between no atrophy and CA+MTA groups.

  • †Significant difference between CA and CA+MTA groups.