Table 2

Univariable analysis of sex-specific associations with NAWM K₂ coefficient

Variable	Women		Men
Variable	Estimate	P values	Estimate	P values
Age	11.3	0.17	36.0	0.04
BMI	−41.8	0.06	−64.0	0.20
Anticoagulant use	523.8	0.20	2.9	0.99
Atrial fibrillation	583.6	0.04	−935.3	0.12
Diabetes	−118.6	0.75	603.2	0.29
Hyperlipidaemia	82.6	0.77	613.2	0.20
Hypertension	−123.4	0.67	−362.2	0.51
Prior stroke/TIA	336.7	0.30	650.6	0.24
Cardioembolic stroke	194.6	0.48	66.7	0.89
Admission NIHSS	40.4	0.07	31.4	0.40
Systolic blood pressure	0.9	0.86	8.0	0.36
MMP-2 level	0.4	0.69	1.4	0.45
IV alteplase treatment	195.5	0.48	−732.6	0.15
HT	413.4	0.17	357.1	0.52
WMHv	31.8	0.04	131.1	0.005
NAWM ADC	4.4	0.02	2.2	0.66
NAWM mask volume	−17.8	0.11	−24.0	0.13

Bold values indicate P value < 0.05.
ADC, apparent diffusion coefficient; BMI, body mass index; HT, haemorrhagic transformation; IV, intravenous; MMP, matrix metalloproteinase; NAWM, normal-appearing white matter; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischemic attack; WMHv, white matter hyperintensity volume.