Table 2

Sensitivity and specificity for predicting LAO for various models at optimum cut-off, high specificity cut-off and high sensitivity cut-off

Model	AUC	P values	Optimum Youden cut-off		High specificity cut-off		High sensitivity cut-off
Model	AUC	P values	Sens	Spec	Sens	Spec	Sens	Spec
NIH item 5	0.72	–	67 (NIHSS 5≥3)	72 (NIHSS 5≥3)	53 (NIHSS 5=4)	81 (NIHSS 5=4)	77 (NIHSS 5≥2)	57 (NIHSS 5≥2)
NIHSS item 5+NIHSS item 2	0.75	<0.05	68	73	64	76	82	53
NIHSS item 5+NIHSS item 2+NIHSS item 4	0.76	<0.05	70	72	61	80	80	59
NIHSS item 5+NIHSS item 2+ NIHSS item 4+NIHSS item 1C	0.76	<0.05	67	75	61	80	79	59
Full-item NIHSS	0.78	<0.05	69	76	62	80	81	59
Total NIHSS score	0.76	<0.05	69	73	60	80	80	57
NIHSS item 5+NIHSS item 6	0.73	<0.05	65	74	53	82	79	52

The p values for the AUCs describe likelihood ratios tests comparing each model with the simple arm paresis model (NIH item 5). For the 1-item model including subitem 5, arm function, we have in italics given the respective subitem cut-off for the three sensitivity/specificity scenarios. NIHSS item 2=gaze; NIHSS item 1C=level of consciousness commands; NIHSS item 4=facial motor function; NIHSS item 5=arm motor function; NIHSS item 6=leg motor function.
AUC, area under the curve; LAO, large artery occlusion; NIHSS, National Institutes of Health Stroke Scale.