RT Journal Article
SR Electronic
T1 Stenting for symptomatic intracranial arterial stenosis in China: 1-year outcome of a multicentre registry study
JF Stroke and Vascular Neurology
FD BMJ Publishing Group Ltd
SP 176
OP 184
DO 10.1136/svn-2017-000137
VO 3
IS 3
A1 Ning Ma
A1 Yong Zhang
A1 Jie Shuai
A1 Changchun Jiang
A1 Qiyi Zhu
A1 Kangning Chen
A1 Li Liu
A1 Baomin Li
A1 Xiangqun Shi
A1 Lianbo Gao
A1 Yajie Liu
A1 Feng Wang
A1 Yongli Li
A1 Tieyan Liu
A1 Hongbo Zheng
A1 Dapeng Mo
A1 Feng Gao
A1 Yilong Wang
A1 Yongjun Wang
A1 Lei Feng
A1 Zhongrong Miao
A1 ,
YR 2018
UL http://svn.bmj.com/content/3/3/176.abstract
AB Background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis (ICAS) combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable. However, it remained uncertain whether the low event rate could be of a long term. We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%–99% stenosis located at the intracranial internal carotid, middle cerebral, intracranial vertebral or basilar arteries combined with poor collaterals were enrolled. Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators. The primary outcome was the rate of 30-day stroke, transient ischaemic attack and death, and 12-month ischaemic stroke within the same vascular territory, haemorrhagic stroke and vascular death after stenting.Results From September 2013 to January 2015, 300 patients (ages 58.3±9.78 years) were recruited. Among them, 159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent. During the 1-year follow-up, 25 patients had a primary end point event. The probability of primary outcome at 1 year was 8.1% (95% CI 5.3% to 11.7%). In 76 patients with digital subtraction angiography follow-up, 27.6% (21/76) had re-stenosis ≥50% and 18.4% (14/76) had re-stenosis ≥70%. No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals. Further randomised trial of comparing individually tailored stenting with best medical therapy is needed.Trial registration number NCT01968122; Results.