PT - JOURNAL ARTICLE AU - Ning Ma AU - Yong Zhang AU - Jie Shuai AU - Changchun Jiang AU - Qiyi Zhu AU - Kangning Chen AU - Li Liu AU - Baomin Li AU - Xiangqun Shi AU - Lianbo Gao AU - Yajie Liu AU - Feng Wang AU - Yongli Li AU - Tieyan Liu AU - Hongbo Zheng AU - Dapeng Mo AU - Feng Gao AU - Yilong Wang AU - Yongjun Wang AU - Lei Feng AU - Zhongrong Miao ED - , TI - Stenting for symptomatic intracranial arterial stenosis in China: 1-year outcome of a multicentre registry study AID - 10.1136/svn-2017-000137 DP - 2018 May 05 TA - Stroke and Vascular Neurology PG - svn-2017-000137 4099 - http://svn.bmj.com/content/early/2018/05/06/svn-2017-000137.short 4100 - http://svn.bmj.com/content/early/2018/05/06/svn-2017-000137.full AB - Background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis (ICAS) combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable. However, it remained uncertain whether the low event rate could be of a long term. We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%–99% stenosis located at the intracranial internal carotid, middle cerebral, intracranial vertebral or basilar arteries combined with poor collaterals were enrolled. Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators. The primary outcome was the rate of 30-day stroke, transient ischaemic attack and death, and 12-month ischaemic stroke within the same vascular territory, haemorrhagic stroke and vascular death after stenting.Results From September 2013 to January 2015, 300 patients (ages 58.3±9.78 years) were recruited. Among them, 159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent. During the 1-year follow-up, 25 patients had a primary end point event. The probability of primary outcome at 1 year was 8.1% (95% CI 5.3% to 11.7%). In 76 patients with digital subtraction angiography follow-up, 27.6% (21/76) had re-stenosis ≥50% and 18.4% (14/76) had re-stenosis ≥70%. No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals. Further randomised trial of comparing individually tailored stenting with best medical therapy is needed.Trial registration number NCT01968122; Results.