TY - JOUR T1 - Differences in left and right carotid plaque vulnerability in patients with bilateral carotid plaques: a CARE-II study JF - Stroke and Vascular Neurology JO - Stroke Vasc Neurol DO - 10.1136/svn-2022-001937 SP - svn-2022-001937 AU - Sai Shao AU - Honglu Shi AU - Guangbin Wang AU - Rui Li AU - Qinjian Sun AU - Bin Yao AU - Hiroko Watase AU - Daniel S Hippe AU - Chun Yuan AU - Xihai Zhao A2 - , Y1 - 2023/01/03 UR - http://svn.bmj.com/content/early/2023/01/03/svn-2022-001937.abstract N2 - Background and purpose Atherosclerosis is a very complex process influenced by various systemic and local factors. Therefore, in patients with bilateral carotid plaques (BCPs), there may be differences in carotid plaque vulnerability between the sides. We aimed to investigate the differences in BCP characteristics in patients with BCPs using magnetic resonance vessel wall imaging (MR-VWI).Methods Participants with BCPs were selected for subanalysis from a multicentre study of Chinese Atherosclerosis Risk Evaluation II. We measured carotid plaque burden, identified each plaque component and measured their volume or area bilaterally on MR-VWI. Paired comparisons of the burden and components of BCPs were performed.Results In all, 540 patients with BCPs were eligible for analysis. Compared with the right carotid artery (CA), larger mean lumen area (p<0.001), larger mean wall area (p=0.025), larger mean total vessel area (p<0.001) and smaller normalised wall index (p=0.006) were found in the left CA. Regarding plaque components, only the prevalence of lipid-rich necrotic core (LRNC) in the left CA was higher (p=0.026). For patients with a vulnerable plaque component coexisting on both sides, only the intraplaque haemorrhage (IPH) volume (p=0.011) was significantly greater in the left CA than in the right CA.Conclusions There were asymmetries in plaque growth and evolution between BCPs. The left carotid plaques were more likely to have larger plaque burden, higher prevalence of LRNC and greater IPH volume, which may contribute to the lateralisation of ischaemic stroke in the cerebral hemispheres.Data are available upon reasonable request. ER -