TY - JOUR T1 - Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study JF - Stroke and Vascular Neurology JO - Stroke Vasc Neurol DO - 10.1136/svn-2022-001924 SP - svn-2022-001924 AU - Yuan Cao AU - Mei-Ying Huang AU - Chen-Hui Mao AU - Xue Wang AU - Yuan-Yuan Xu AU - Xiao-Jing Qian AU - Chao Ma AU - Wen-Ying Qiu AU - Yi-Cheng Zhu Y1 - 2022/12/29 UR - http://svn.bmj.com/content/early/2022/12/28/svn-2022-001924.abstract N2 - Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenised venules has not been clarified. Here, we aimed to investigate the associations between microvascular injuries, including arteriolosclerosis and venular collagenosis, and related parenchymal damages in ageing brains, to investigate the underlying correlations.Methods We evaluated arteriolosclerosis and venular collagenosis in 7 regions from 27 autopsy cases with no history of stroke or brain tumour. The correlations between the ratio of arteriolosclerosis, venular collagenosis and the severity of cerebrovascular parenchymal damage, including lacunes, microinfarcts, myelin loss, and parenchymal and perivascular haemosiderin deposits, were assessed.Results Arteriolosclerosis and venular collagenosis became more evident with age. Arteriolosclerosis was associated with lacunes (p=0.004) and brain parenchymal haemosiderin deposits in the superior frontal cortex (p=0.024) but not with leukoaraiosis severity. Venular collagenosis was not associated with the number of lacunes or haemosiderin, while white matter generally became paler with severe venular collagenosis in the periventricular (β=−0.430, p=0.028) and deep white matter (β=−0.437, p=0.025).Conclusion Our findings imply an important role for venular lesions in relation to microvessel-related parenchymal damage which is different from that for arteriolosclerosis. Different underlying mechanisms of both cerebral arterioles and venules require further investigation.All data relevant to the study are included in the article or uploaded as online supplemental information. ER -