RT Journal Article SR Electronic T1 sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 528 OP 535 DO 10.1136/svn-2020-000684 VO 6 IS 4 A1 Andrés da Silva-Candal A1 Iria López-Dequidt A1 Manuel Rodriguez-Yañez A1 Paulo Ávila-Gómez A1 José Manuel Pumar A1 José Castillo A1 Tomás Sobrino A1 Francisco Campos A1 Ramón Iglesias-Rey A1 Pablo Hervella YR 2021 UL http://svn.bmj.com/content/6/4/528.abstract AB Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis (LA) and the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) in patients with intracerebral haemorrhage (ICH).Methods This is a retrospective observational study of patients with nontraumatic ICH. Clinical and biochemical parameters were analysed. sTWEAK levels were measured by ELISA. LA was analysed in the hemisphere without haemorrhage to avoid interference with the acute injury. The main endpoint was the haematoma growth evaluated by the difference in volume between the second and the initial neuroimage. Poor functional outcome, defined as a modified Rankin Scale >2 at 3 months, was considered as secondary endpoint. Receiver operating characteristic curve analysis was performed to stablish the best cut-off for sTWEAK levels associated with haematoma growth.Results We included 653 patients with ICH in our analysis (71.1±11.9 years, 44% women). Haematoma growth was observed in 188 patients (28.8%). sTWEAK levels ≥5600 pg/mL predicted ICH growth with a sensitivity of 84% and a specificity of 87%. sTWEAK levels ≥5600 pg/mL and the presence of LA were associated with haematoma growth (OR: 42.46; (CI 95% 22.67 to 79.52) and OR: 2.73 (CI 95% 1.39 to 5.34), respectively). Also, the presence of LA (OR: 4.31 (CI 95% 2.89 to 6.42)) and the interaction between ICH growth and sTWEAK (OR: 2.23 (CI 95% 1.40 to 3.55)) were associated with poor functional outcome at 3 months.Conclusion sTWEAKs, together with the presence and grade of LA, are biomarkers able to predict ICH growth and poor functional outcome in patients with ICH.Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. All data are available within the text of the manuscript. Further anonymized data could be made available to qualified investigators upon reasonable request.