TY - JOUR T1 - Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations JF - Stroke and Vascular Neurology JO - Stroke Vasc Neurol SP - 589 LP - 594 DO - 10.1136/svn-2020-000813 VL - 6 IS - 4 AU - Mei-Jun Shu AU - Fei-Fei Zhai AU - Ding-Ding Zhang AU - Fei Han AU - Lixin Zhou AU - Jun Ni AU - Ming Yao AU - Shu-Yang Zhang AU - Li-Ying Cui AU - Zheng-Yu Jin AU - Hui-Juan Zhu AU - Yi-Cheng Zhu Y1 - 2021/12/01 UR - http://svn.bmj.com/content/6/4/589.abstract N2 - Background and purpose This study aimed to investigate the association of metabolic syndrome (MetS) with both intracranial atherosclerotic stenosis (ICAS) and imaging markers of cerebral small vessel disease (CSVD) in a community-based sample.Methods This study included 943 participants (aged 55.6±9.2 years, 36.1% male) from the community-based Shunyi cohort study. MetS was defined according to the joint interim criteria and quantified by the MetS severity Z-score. ICAS was evaluated by brain magnetic resonance angiography. The MRI markers of CSVD, including white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS), were assessed. Multiple regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD markers.Results We found that risk of ICAS (OR=1.75, 95% CI 1.39 to 2.21, p<0.001) increased consistently with MetS severity. MetS severity was significantly associated with higher risks of WMH volume (β=0.11, 95% CI 0.01 to 0.20, p=0.02) and lacunes (OR=1.28, 95% CI 1.03 to 1.59, p=0.03) but not the presence of CMBs (OR=0.93, 95% CI 0.74 to 1.16, p=0.51) and PVS severity (EPVS in basal ganglia: OR=0.96, 95% CI 0.84 to 1.09, p=0.51 and EPVS in white matter: OR=1.09, 95% CI 0.96 to 1.23, p=0.21).Conclusions Our findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery, whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak.All data relevant to the study are included in the article or uploaded as supplementary information. ER -