PT  - JOURNAL ARTICLE
AU  - Benno Ikenberg
AU  - Antonia Franziska Demleitner
AU  - Thomas Thiele
AU  - Benedikt Wiestler
AU  - Katharina Götze
AU  - Georg Mößmer
AU  - Paul Lingor
TI  - Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
AID  - 10.1136/svn-2021-001095
DP  - 2021 Dec 01
TA  - Stroke and Vascular Neurology
PG  - 668--670
VI  - 6
IP  - 4
4099  - http://svn.bmj.com/content/6/4/668.short
4100  - http://svn.bmj.com/content/6/4/668.full
SO  - Stroke Vasc Neurol2021 Dec 01; 6
AB  - Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.