PT - JOURNAL ARTICLE AU - Benno Ikenberg AU - Antonia Franziska Demleitner AU - Thomas Thiele AU - Benedikt Wiestler AU - Katharina Götze AU - Georg Mößmer AU - Paul Lingor TI - Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan AID - 10.1136/svn-2021-001095 DP - 2021 Jul 08 TA - Stroke and Vascular Neurology PG - svn-2021-001095 4099 - http://svn.bmj.com/content/early/2021/07/08/svn-2021-001095.short 4100 - http://svn.bmj.com/content/early/2021/07/08/svn-2021-001095.full AB - Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.