RT Journal Article SR Electronic T1 In-hospital complications affect short-term and long-term mortality in ICH: a prospective cohort study JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 201 OP 206 DO 10.1136/svn-2020-000386 VO 6 IS 2 A1 Yaqing Zhang A1 Yongjun Wang A1 Ruijun Ji A1 Anxin Wang A1 Yilong Wang A1 Zhonghua Yang A1 Liping Liu A1 Penglian Wang A1 Xingquan Zhao A1 , YR 2021 UL http://svn.bmj.com/content/6/2/201.abstract AB Background Medical complications strongly affected the mortality of patients with stroke. However, only limited research has studied the effect of in-hospital medical complications on the mortality of patients with spontaneous intracerebral haemorrhage (ICH) globally. Using the China National Stroke Registry, the effect was prospectively and systematically investigated in patients with spontaneous ICH during their hospitalisation, at 3, 6 and 12 months after disease onset.Methods This study collected data on patients over 18 years old with spontaneous ICH from 132 Chinese clinical centres across 32 provinces and four municipalities (Hong Kong included), from September 2007 to August 2008. Data on patient complications, death and other information were acquired through paper-based registry forms. Using multivariable logistic regression, the association of medical complications with stroke outcomes was evaluated.Results Of 3255 patients with spontaneous ICH, 878 (26.97%) had in-hospital medical complications. In-hospital medical complications were independent risk factors for death during the hospitalisation (adjusted OR 4.41, 95% CI 3.18 to 6.12), at 3 months (adjusted OR 2.18, 95% CI 1.70 to 2.80), 6 months (adjusted OR 1.84, 95% CI 1.45 to 2.34) and 12 months (adjusted OR 1.59, 95% CI 1.26 to 2.01) after spontaneous ICH.Conclusion The results revealed that the short-term and long-term mortality of patients with spontaneous ICH in China was significantly associated with their in-hospital medical complications.All data relevant to the study are included in the article or uploaded as supplementary information. The data are available from XZ, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Tel: +86-10-59978350. Fax: +86-1059973383. Email address: zxq@vip.163.com. The data reuse is permitted under the corresponding author's permission.