RT Journal Article
SR Electronic
T1 Cellular and molecular imaging for stem cell tracking in neurological diseases
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP 121
OP 127
DO 10.1136/svn-2020-000408
VO 6
IS 1
A1 Xiaoxia Yang
A1 De-Cai Tian
A1 Wenyan He
A1 Wei Lv
A1 Junwan Fan
A1 Haowen Li
A1 Wei-Na Jin
A1 Xia Meng
YR 2021
UL http://svn.bmj.com/content/6/1/121.abstract
AB Stem cells (SCs) are cells with strong proliferation ability, multilineage differentiation potential and self-renewal capacity. SC transplantation represents an important therapeutic advancement for the treatment strategy of neurological diseases, both in the preclinical experimental and clinical settings. Innovative and breakthrough SC labelling and tracking technologies are widely used to monitor the distribution and viability of transplanted cells non-invasively and longitudinally. Here we summarised the research progress of the main tracers, labelling methods and imaging technologies involved in current SC tracking technologies for various neurological diseases. Finally, the applications, challenges and unresolved problems of current SC tracing technologies were discussed.