@article {Chen65, author = {Yu Chen and Ruinan Li and Li Ma and Xiangyu Meng and Debin Yan and Hao Wang and Xun Ye and Hengwei Jin and Youxiang Li and Dezhi Gao and Shibin Sun and Ali Liu and Shuo Wang and Xiaolin Chen and Yuanli Zhao}, title = {Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience}, volume = {6}, number = {1}, pages = {65--73}, year = {2021}, doi = {10.1136/svn-2020-000407}, publisher = {BMJ Specialist Journals}, abstract = {Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations (AVMs) after different management modalities.Methods The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and 2017. The rupture risk was represented by annualised haemorrhagic rate. Patients were divided into five groups: conservation, microsurgery, embolisation, stereotactic radiosurgery (SRS) and embolisation+SRS. Neurofunctional outcomes were evaluated by the modified Rankin Scale (mRS). Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured cohorts.Results All of 61 brainstem AVMs (12 unruptured and 49 ruptured) were followed up for an average of 4.5 years. The natural annualised rupture risk was 7.3\%, and the natural annualised reruptured risk in the ruptured cohort was 8.9\%. 13 cases were conservative managed and 48 cases underwent intervention (including 6 microsurgery, 12 embolisation, 21 SRS and 9 embolisation+SRS). In the selection of interventional indication, diffuse nidus were often suggested conservative management (p=0.004) and nidus involving the midbrain were more likely to be recommended for intervention (p=0.034). The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management (p\<0.001, p=0.036, respectively). In the subgroup analysis, the follow-up mRS scores of different management modalities were similar whether in the rupture cohort (p=0.064) or the unruptured cohort (p=0.391), as well as the haemorrhage-free survival (p=0.145). In the adjusted Bonferroni correction analysis of the ruptured cohort, microsurgery and SRS could significantly improve the obliteration rate compared with conservation (p\<0.001, p=0.001, respectively) and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation (p=0.003, p=0.003, respectively).Conclusions Intervention has similar neurofunctional outcomes as conservation in these brainstem AVM cohorts. If intervention is adopted, partial obliteration should be avoided because of the high subsequent rupture risk.Trial registration number NCT04136860.}, issn = {2059-8688}, URL = {https://svn.bmj.com/content/6/1/65}, eprint = {https://svn.bmj.com/content/6/1/65.full.pdf}, journal = {Stroke and Vascular Neurology} }