TY - JOUR T1 - Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack JF - Stroke and Vascular Neurology JO - Stroke Vasc Neurol DO - 10.1136/svn-2020-000676 SP - svn-2020-000676 AU - Hongyu Zhou AU - Anxin Wang AU - Xia Meng AU - Jinxi Lin AU - Yong Jiang AU - Jing Jing AU - Yingting Zuo AU - Yilong Wang AU - Xingquan Zhao AU - Hao Li AU - Yongjun Wang Y1 - 2021/02/25 UR - http://svn.bmj.com/content/early/2021/02/25/svn-2020-000676.abstract N2 - Background To examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association.Methods We analysed data from the Third China National Stroke Registry (CNSR-Ⅲ). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis.Results A total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in <35 g/L group had an increased risk of poor functional outcome and mortality (adjusted OR 1.37 (95% CI 1.12 to 1.67); adjusted HR 2.13 (95% CI 1.41 to 3.23)). The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed (adjusted OR 1.17 (95% CI 1.01 to 1.35); adjusted HR 1.86 (95% CI 1.30 to 2.64)). Also, low serum albumin levels were independently correlated with clinical outcomes at 1 year. In the meta-analysis, the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03 (95% CI 1.02 to 1.05), and the HR for mortality pooled 5 studies was 1.07 (95% CI 1.03 to 1.11).Conclusions Low serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA. ER -