RT Journal Article SR Electronic T1 Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 177 OP 179 DO 10.1136/svn-2020-000398 VO 5 IS 2 A1 Yifan Zhou A1 Wei Li A1 David Wang A1 Ling Mao A1 Huijuan Jin A1 Yanan Li A1 Candong Hong A1 Shengcai Chen A1 Jiang Chang A1 Quanwei He A1 Mengdie Wang A1 Bo Hu YR 2020 UL http://svn.bmj.com/content/5/2/177.abstract AB Coronavirus disease-2019 (COVID‐19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1–2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. The key is to prevent a patient from progressing to this severe infection from mild infection. We are sharing our experience on prevention and management of COVID-19.