RT Journal Article SR Electronic T1 Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 97 OP 102 DO 10.1136/svn-2019-000316 VO 5 IS 1 A1 Peicong Ge A1 Qian Zhang A1 Xun Ye A1 Xingju Liu A1 Xiaofeng Deng A1 Jia Wang A1 Rong Wang A1 Yan Zhang A1 Dong Zhang A1 Ji Zong Zhao YR 2020 UL http://svn.bmj.com/content/5/1/97.abstract AB Background Evidence on the natural angiographic course of moyamoya disease (MMD) is lacking. It takes about 6 months for waiting for revascularisation surgery. The issue of when to perform subtraction angiography (DSA) for follow-up remains unclear. We investigated the natural course of MMD by DSA and attempted to determine the best interval to perform the follow-up DSA.Methods This is a single-centre cohort study of Chinese MMD inpatients treated from 1 January 2015 to 31 August 2019. Their angiographic findings were evaluated on Suzuki stage and collateral circulation between two follow-ups of the same hemisphere.Results A total of 110 patients who met the criteria were enrolled in this study. After a median 6 months follow-up, five patients (4.5%) had progression, four females and one male. Time interval of progression ranged from 4 to 137 months with a mean of 61.4 months. Of five patients with progression, four had unilateral lesion (two ipsilateral and two contralateral) and one had bilateral lesions. Collateral circulation was changed in three of five patients.Conclusions The angiographic evidence of progression in MMD was rare in the short-term follow-up, and most patients with progression had initial unilateral involvement. DSA re-examination may be not needed in patients with bilateral MMD, but needed in unilateral MMD.