RT Journal Article
SR Electronic
T1 Neuroimaging studies on cognitive impairment due to cerebral small vessel disease
JF Stroke and Vascular Neurology
FD BMJ Publishing Group Ltd
SP 99
OP 101
DO 10.1136/svn-2018-000209
VO 4
IS 2
A1 Du, Jing
A1 Xu, Qun
YR 2019
UL http://svn.bmj.com/content/4/2/99.abstract
AB Vascular cognitive impairment (VCI) is a major contributor to age-related dementing illnesses which imposes a tremendous burden on families and society. It is a heterogeneous group of brain disorders. However, cerebral small vessel disease (CSVD) accounts for about 50%–70% of VCI, which represented a more homogeneous subtype of VCI. Advanced multimodal neuroimaging techniques like brain network connectome analyses are currently applied to explore the underlying mechanism of VCI. Some progress in the field of structural and functional brain network researches on a poststroke longitudinal CSVD cohort (Renji CSVD Cohort Study) was reported. Global and regional brain network characters were compared between patients with CSVD and healthy control. It suggested that distributed brain structural network disruption may play a pivot role in the cognitive decline. The results showed that brain structural network characters have distinctive differentiating capacity on the cognition of patients with CSVD.