Centenarians (CENs) are excellent subjects to study the mechanisms of human longevity
and healthy aging. Here, we analyzed the transcriptomes of 76 centenarians, 54 …

Autophagy is a critical quality control pathway that is conserved across diverse systems
ranging from simple unicellular organisms like yeast to more complex systems, for instance …

Autophagy is a fundamental multi-tasking adaptive cellular degradation and recycling
strategy. Following its causal implication in age-related decline, autophagy is currently …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging Page 1
Molecular Cell Spotlight Self-Digestion for Lifespan Extension: Enhanced Autophagy …

Ageing in divergent animal phyla is influenced by several evolutionarily conserved
signalling pathways, mitochondrial activity and various environmental factors such as …

Caloric restriction (CR) is an important means to delay senescence, and glucose restriction
is one of the measures to achieve CR. On the basis of our previous work and bioinformatics …

Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …

Autophagy is a ubiquitous catabolic process, which causes cellular bulk degradation
through vesicular engulfment of obsolete, damaged or harmful cytoplasmic components …

Autophagy is a major clearance mechanism that degrades organelles and large protein
aggregates to maintain cell survival and protein homeostasis. Although induction of …