You are here

Article Text

Article menu

Download PDFPDF

Review
Cellular and molecular imaging for stem cell tracking in neurological diseases
  1. Xiaoxia Yang1,2,
  2. De-Cai Tian1,
  3. Wenyan He1,
  4. Wei Lv1,
  5. Junwan Fan1,
  6. Haowen Li1,
  7. Wei-Na Jin1,
  8. Xia Meng1
  1. 1 China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing Tiantan Hospital, Beijing, China
  2. 2 Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
  1. Correspondence to Dr Xia Meng; mengxia{at}ncrcnd.org.cn; Dr Wei-Na Jin; wingkingweina{at}hotmail.com

Abstract

Stem cells (SCs) are cells with strong proliferation ability, multilineage differentiation potential and self-renewal capacity. SC transplantation represents an important therapeutic advancement for the treatment strategy of neurological diseases, both in the preclinical experimental and clinical settings. Innovative and breakthrough SC labelling and tracking technologies are widely used to monitor the distribution and viability of transplanted cells non-invasively and longitudinally. Here we summarised the research progress of the main tracers, labelling methods and imaging technologies involved in current SC tracking technologies for various neurological diseases. Finally, the applications, challenges and unresolved problems of current SC tracing technologies were discussed.

  • MRI
  • brain
  • technique
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/svn-2020-000408

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • XY and D-CT are joint first authors.

    • Contributors XM and W-NJ formulated the study concept and designed the studies; XY and DT wrote and edited the manuscript; WH, WL, JF and HL assisted preparation of the manuscript.

    • Funding This study was funded by National Science Foundation of China (81801199, 81830038, 81971094, 91949208), Beijing Municipal Science & Technology Commission (Z181100001818001).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.