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Prognostic value of systemic immune–inflammation index in acute/subacute patients with cerebral venous sinus thrombosis
  1. Shen Li,
  2. Kai Liu,
  3. Yuan Gao,
  4. Lu Zhao,
  5. Rui Zhang,
  6. Hui Fang,
  7. Yongli Tao,
  8. Hongbing Liu,
  9. Jiawei Zhao,
  10. Zongping Xia,
  11. Yuming Xu,
  12. Bo Song
  1. Department of Neurology, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan, China
  1. Correspondence to Bo Song; songbo76{at}


Objective To evaluate the prognosis values of systemic immune–inflammation index (SII) in non-chronic cerebral venous sinus thrombosis (CVST).

Methods patients with CVST, admitted to the First Affiliated Hospital of Zhengzhou University, were retrospectively identified from January 2013 to December 2018. We selected patients in acute/subacute phase from database. Functional outcomes of patients were evaluated with the modified Rankin Scale (mRS)—mRS 3–6 as poor outcomes and mRS 6 as death. The overall survival time was defined as the date of onset to the date of death or last follow-up date. Survival analysis was described by the Kaplan-Meier curve and Cox regression analysis. Multivariate logistic regression analysis assessed the relationship between SII and poor functional outcome. The area under the Receiver Operating Curve curve (AUC) was estimated to evaluate the ability of SII in prediction.

Results A total of 270 patients were included and their duration of follow-up was 22 months (6–66 months), of whom 31 patients had poor outcomes and 24 patients dead. Cox regression analysis showed that SII (HR=1.304, 95% CI: 1.101 to 1.703, p=0.001) was a predictor of death in non-chronic CVST. Patients with higher SII presented lower survival rates (p=0.003). The AUC of SII was 0.792 (95% CI: 0.695 to 0.888, p=0.040) with a sensitivity of 69.6% and specificity of 80.1%. Subgroups analysis demonstrated that SII was an important predictor of poor outcomes in male (OR=1.303, 95% CI: 1.102 to 1.501, p=0.011) and pregnancy/puerperium female (OR=1.407, 95% CI: 1.204 to 1.703, p=0.034).

Conclusions SII was a potential predictor in the poor prognosis of patients with acute/subacute CVST, especially in male and pregnancy/puerperium female.

  • inflammation
  • stroke
  • vein

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  • Contributors SL is the first author. BS, YX and ZX provided funding and designed the study. YT, HL and JZ collected the data. YG, LZ, RZ and HF were involved in data cleaning, follow-up and verification. KL revised the article. All authors have read and approved the final manuscript.

  • Funding This work was supported by the Science and Technology Department of the Henan Province grant number (No.152102310058), the National Natural Science Foundation of China grant number (Nos. 81530037).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The retrospective cohort study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information. All data relevant to the study are included in the article or uploaded as supplementary information.

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