Article Text

Download PDFPDF

Dynamic contrast-enhanced MRI analysis for prognosis of intracranial dissecting aneurysm with intramural haematoma after endovascular treatment: an observational registry study
  1. Zhongbin Tian,
  2. Zhongxiao Wang,
  3. Wenqiang Li,
  4. Wei Zhu,
  5. Jian Liu,
  6. Ying Zhang,
  7. Xinjian Yang,
  8. Yisen Zhang
  1. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Beijing, China
  1. Correspondence to Dr Yisen Zhang; zhangyisen{at}


Background and purpose Intracranial dissecting aneurysm (IDA) with intramural haematoma (IMH) is an intractable cerebrovascular disease. The outcome of IDA with IMH after endovascular treatment varies across different individuals: some IMHs stop growing after endovascular treatment, while others continue to grow, even after embolisation of the parent artery. Currently, the mechanism for the continuous growth of IMH after endovascular treatment is still unclear. Continuous haemorrhage of the vasa vasorum in the IMH is considered to be associated with continuous enlargement of the IMH; however, this theory has not been proved by in vivo imaging.

Methods and analysis This study will establish a prospective cohort of 80 patients who had an IDA with IMH and received endovascular treatment. Demographic characteristics, IDA morphological characteristics and treatment characteristics will be collected prospectively. All patients will undergo dynamic contrast-enhanced MRI (DCE-MRI) before and 6 months after the endovascular treatment. According to the follow-up results of the MRI, the IDAs will be divided into two groups: a haematoma stabilisation group and a haematoma enlargement group. Then, quantitative analysis of the vasa vasorum in the IMH will be performed, and differences between the two groups will be compared with determine the association between DCE-MRI related parameters and the outcomes of IMH changes.

Ethics and dissemination The research was approved by the ethics committee of Beijing Tian Tan Hospital (KY 2019-024-03) and written informed consents would be obtained from all patients included in this study. The results of this study will be disseminated in professional printed media.

Trial registration number NCT03940859. Registered: 7 May, 2019.

  • dissection
  • MRI
  • intervention

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Correction notice This paper has been updated since first published to update article type.

  • Contributors ZT performed the manuscript writing. YZ and XY made critical revision to the manuscript for important intellectual content. ZW, WL, WZ and JL all participated in the final design of the study. YZ conceived and designed the research, and handled funding and supervision. All authors read and approved the final manuscript.

  • Funding This work was supported by the National Natural Science Foundation of China (grant numbers: 81801158, 81801156, 81471167 and 81671139) and the Special Research Project for Capital Health Development (grant number: 2018-4-1077).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The research was permitted by the ethics committee of Beijing Tian Tan Hospital (KY 2019-024-03) and written informed consents would be obtained from all patients included in this study. This study adheres to the ethical principles of the Declaration of Helsinki and Human Biomedical Research Ethical Issues and Policy Guidance.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.