Article Text

Download PDFPDF

The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
  1. Yongjun Wang1,2,3,4,
  2. Jing Jing1,2,3,4,
  3. Xia Meng1,2,3,4,
  4. Yuesong Pan1,2,3,4,
  5. Yilong Wang1,2,3,4,
  6. Xingquan Zhao1,2,3,4,
  7. Jinxi Lin1,2,3,4,
  8. Wei Li1,2,3,4,
  9. Yong Jiang1,2,3,4,
  10. Zixiao Li1,2,3,4,
  11. Xinmiao Zhang1,2,3,4,
  12. Xiaomeng Yang1,2,3,4,
  13. Ruijun Ji1,2,3,4,
  14. Chunjuan Wang1,2,3,4,
  15. Zhimin Wang5,
  16. Xinsheng Han6,
  17. Songdi Wu7,
  18. Zhengchang Jia8,
  19. Yongming Chen9,
  20. Hao Li1,2,3,4
  1. 1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  2. 2 China National Clinical Research Center for Neurological Diseases, Beijing, China
  3. 3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
  4. 4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
  5. 5 Department of Neurology, The First people’s Hospital of Taizhou, Taizhou, China
  6. 6 Department of Neurology, The Kaifeng Central Hospital, Kaifeng, China
  7. 7 Department of Neurology, The First People’s Hospital of Xi’an, Xi’an, China
  8. 8 Department of Neurology, The Second People’s Hospital of Jinzhong, Jinzhong, China
  9. 9 Department of Neurology, WuYuan County People’s Hospital, Bayannur, China
  1. Correspondence to Dr Yongjun Wang; yongjunwang{at}


Background and purpose Stroke is the leading cause of mortality and disability in China. Precise aetiological classification, imaging and biological markers may predict the prognosis of stroke. The Third China National Stroke Registry (CNSR-III), a nationwide registry of ischaemic stroke or transient ischaemic attack (TIA) in China based on aetiology, imaging and biology markers, will be considered to clarify the pathogenesis and prognostic factors of ischaemic stroke.

Methods Between August 2015 and March 2018, the CNSR-III recruited consecutive patients with ischaemic stroke or TIA from 201 hospitals that cover 22 provinces and four municipalities in China. Clinical data were collected prospectively using an electronic data capture system by face-to-face interviews. Patients were followed for clinical outcomes at 3 months, 6 months and 1–5 year annually. Brain imaging, including brain MRI and CT, were completed at baseline. Blood samples were collected and biomarkers were tested at baseline.

Results A total of 15 166 stroke patients were enrolled, among which 31.7% patients were women with the average age of 62.2±11.3 years. Ischaemic stroke was predominant (93.3%, n=14 146) and 1020 (6.7%) TIAs were enrolled.

Conclusions CNSR-III is a large scale nationwide registry in China. Data from this prospective registry may provide opportunity to evaluate imaging and biomarker prognostic determinants of stroke.

  • stroke
  • registry
  • transient ischaemic attack
  • biomarker
  • outcome

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

View Full Text

Statistics from


  • Contributor YoW had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: YoW, JJ, XM, YiW and RJ. Supplying patients: ZW, XH, SW, ZJ and YC. Drafting of the manuscript: YoW, YP and HL. Critical revision of the manuscript for important intellectual content: YiW, XZ and HL. Statistical analysis: YP, HL and YJ. Study supervision and organisation of the project: YoW, XM, JL, WL, ZL, XZ, XY and CW.

  • Funding This study was supported by grants from the Ministry of Science and Technology of the People’s Republic of China (2016YFC0901001, 2016YFC0901002, 2017YFC1310901, 2017YFC1310902, 2018YFC1311700 and 2018YFC1311706), and grants from Beijing Municipal Commission of Health and Family Planning (No.2016-1-2041, SML20150502).

  • Competing interests None declared.

  • Ethics approval The protocol of the CNSR-III study was approved by ethics committee at Beijing Tiantan Hospital (IRB approval number: KY2015-001-01) and all participating centres.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.