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Lower lymphocyte to monocyte ratio is a potential predictor of poor outcome in patients with cerebral venous sinus thrombosis
  1. Shen Li1,
  2. Kai Liu1,
  3. Rui Zhang1,
  4. Yuan Gao1,
  5. Hui Fang1,
  6. Xinjing Liu1,
  7. Lulu Pei1,
  8. L-Ying Richard Chou2,
  9. Sheng Guan1,
  10. Xinbin Guo1,
  11. Haowen Xu1,
  12. Bo Song1,
  13. Yuming Xu1
  1. 1 Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  2. 2 Cardio-Neurology Clinic and Clinical Proteomics Research Center and Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to Professor Yuming Xu; xuyuming{at}


Background Lymphocyte to monocyte ratio (LMR) is associated with functional outcome in patients with stroke. But the relationship between the LMR value and the prognosis of cerebral venous sinus thrombosis (CVST) has not been investigated.

Methods CVST patients, admitted to the First Affiliated Hospital of Zhengzhou University, were retrospectively identified from November 2010 to January 2017. Functional outcomes of patients were evaluated with the modified Rankin Scale (mRS). Patients were divided into good (mRS 0–2) and poor (mRS 3–6) outcomes groups. Univariate and multivariate Cox regression analyses were used to assess the relationship between LMR and the poor survival outcome.

Results A total of 228 patients were included of which 41 had poor outcomes (18.0%). The duration of follow-up was 22 months (6–66 months). LMR (2.3±1.2 vs 3.2±1.8, p<0.01) was significantly lower in the poor outcome group. Multivariate Cox regression analysis showed that LMR (HR 0.726, 95% CI 0.546 to 0.964, p=0.027) was a independent predictor of poor prognosis.

Conclusions LMR may be a predictor of poor prognosis in CVST patients.

  • cerebral venous sinus thrombosis
  • lymphocyte to monocyte ratio
  • prognosis

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  • SL and KL contributed equally.

  • Contributors SL and KL are joint first authors. YX and BS provided funding and designed the study. LP, SG, XG and HX collected the data. RZ, YG, HF and XL were involved in data cleaning, follow-up and verification. L-YC revised the article. All authors have read and approved the final manuscript.

  • Funding This work was supported by the Science and Technology Department of the Henan Province grant number (No.152102310058), the National Natural Science Foundation of China grant number (No 81530037) and the China Scholarship Council (to KL).

  • Competing interests None declared.

  • Ethics approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the Committee on Publication Ethics (COPE) and the retrospective cohort study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

  • Patient consent for publication Obtained.

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