Article Text
Abstract
Stroke is a cerebrovascular disease displaying high mortality and morbidity. Despite extensive efforts, only very few therapies are available for stroke patients as yet. Hydrogen sulfide (H2S) is thought to be a signalling molecule that is endogenously produced and plays functional roles in the central nervous system. Currently, numerous studies show that H2S impacts stroke outcomes in animal and cellular models. Here, we review the recent research regarding the effects of endogenously produced H2S as well as exogenous H2S donors on stroke pathology, focusing on the potential of H2S-based therapies in treating ischaemic stroke. We also discuss the several issues that hinder the clinical translation of H2S-based therapies from the bench. Taken together, we think that H2S-based therapies are promising strategies for treating cerebral ischaemia if we successfully address these issues.
- hydrogen sulfide
- neuroprotection
- ischemic stroke
- neurotoxicity
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Footnotes
JJ and JL contributed equally.
Contributors JJ contributed to manuscript drafting; JL contributed to manuscript revision; JC reviewed and approved the final manuscript.
Funding This work was supported by the following grants: National Natural Science Foundation of China (81671310, 81571124 and 81471336), Priority Academic Program Development of the Jiangsu Higher Education Institutions, Suzhou Clinical Research Center of Neurological Disease (Szzx201503) and the Jiangsu key laboratory grant (BM2013003).
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
Data sharing statement No additional data are available.
Patient consent for publication Not required.