Chest
Clinical InvestigationsPULMONARY FUNCTION TESTSRelation Between Lung Function and RBC Distribution Width in a Population-Based Study*
Section snippets
Study Population
This study was performed in a random sample of the general population from among residents of western New York who were between the ages 35 and 79 years. The details of the study design, random selection of participants, exclusion criteria, laboratory variability, analytical methods, and spirometry have been described previously.15 One thousand six hundred sixteen participants were included in the analysis. The study was approved by the institutional review board of the University at Buffalo.
Data Collection
A
Study Population
Table 1 shows the baseline characteristics of the 1,616 participants by gender. The age of the subjects ranged from 36 to 80 years. More than one third of men (33.9%) and more than half of women (50.9%) had never smoked. The proportions of former and current smokers are shown in (Table 1). The percentages of current smokers among men and women were only 12.2% and 15%, respectively.
Spirometry, Blood Vitamin Levels, and RBC Indexes
Absolute FEV1 and FVC were higher in men, but FEV1 percent predicted was lower in men than in women. Women had
Discussion
The present study examined the relation between RDW and lung function in a sample of individuals from the general population of western New York. The RDW is the width of the frequency distribution curve of the RBC volume (one SD) divided by the mean RBC volume.18 Only increased levels of RDW have been associated with pathologic states. For example, both microcytic and macrocytic anemias have contrasting effects on mean corpuscular volume, but both conditions increase RDW. It has little
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