Characteristics of direct-acting oral anticoagulants
| Characteristic | Rivaroxaban | Dabigatran | Apixaban | Edoxaban |
| Target | Factor Xa | Factor IIa | Factor Xa | Factor Xa |
| Prodrug | No | Yes | No | No |
| Dosing | Once daily | Twice daily | Twice daily | Once daily |
| Bioavailability | 80%–100% | 6.5% | 50% | 62% |
| Half-life | 5–13 hours | 12–14 hours | 8–15 hours | 10–14 hours |
| Renal clearance | ~33% | 85% | ~27% | ~50% |
| Cmax | 2–4 hours | 1–2 hours | 3–4 hours | 1–2 hours |
| Interactions | Strong inhibitors of CYP3A4 and P-gp | P-gp inhibitors | Strong inhibitors of CYP3A4 and P-gp | P-gp inhibitors |
CYP3A4, intestinal cytochrome P450 3A4; P-gp, P-glycoprotein.