Yan et al
33/2015/China |
The medical costs did not include the cost after discharge The study used charges not real costs The study used data from a single hospital in China
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Boudreau et al
24/2014/USA |
The results were specific to the assumptions and the data used QALYs were derived by using multiple inconsistent studies Long-term cost, QALYs, disabilities and mortality data were limited and dated
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Pan et al
34/2014/China |
Inaccurate estimate for each component of rtPA-associated cost Informal caregiving costs were not included The study did not model changes in functional status from causes other than stroke The study used the efficacy and the utility data from studies in high-income countries
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Boudreau et al
25/2013/USA |
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Kazley et al
26/2013/USA (SC) |
The study examined only a single state The assumptions and data used in the study did not fully represent the clinical practise situation Data do not represent the current year The study may underestimate the benefit because of previously validated model with conservative estimates The study only considered treatment within 3 hours after stroke onset (not up to 4.5 hours)
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Tan Tanny et al
31/2013/Australia |
The study assumed that survival and quality of life would not change between 90 days and 12 months after stroke Efficacy data were drawn from analyses of studies of rtPA being given between 3 and 4.5 hours (not rtPA within 4.5 hours)
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Tung et al
27/2011/USA |
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Johnston28/2010/USA |
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Ehlers et al
37/2007/Denmark |
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Mar et al
38/2005/Spain |
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Chambers et al
30/2002/UK |
Limited published data about the cost of care for stroke survivors Indirect costs, informal care costs and quality of life of other family members were excluded from the model No sufficient published information on resource use, rates of recurrence or disability and mortality by age group The variability of parameter estimates is not well known
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Sinclair et al
35/2001/Canada |
Short-term hospitalisation cost based on a small sample size of 22 patients from a single centre (generalisability) There was a difficulty in determining the costs of stroke care and services in Canada on a ‘per patient basis’ The study used a point estimate without a formal quantitative estimate of its precision
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Fagan et al
9/1998/USA |
The study used a placebo group from the NINDS rtPA Stroke Trial as the source of data for some aspects of the cost analysis The protocol precluded antithrombotic therapy in the first 24 hours after stroke onset, which may affect cost and health outcomes
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