RT Journal Article
SR Electronic
T1 Stroke-induced immunosuppression and poststroke infection
JF Stroke and Vascular Neurology
FD BMJ Publishing Group Ltd
SP svn-2017-000123
DO 10.1136/svn-2017-000123
A1 Kaibin Shi
A1 Kristofer Wood
A1 Fu-Dong Shi
A1 Xiaoying Wang
A1 Qiang Liu
YR 2018
UL http://svn.bmj.com/content/early/2018/01/12/svn-2017-000123.abstract
AB Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system.